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March 29, 2021Open Access

Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction

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Why the study?

Hypertension is a prevalent chronic disease, but whether the PDE4-cAMP-PKA pathway influences hypertension was unknown.

Does Pde4d knockout attenuate Ang II-induced hypertension and vascular remodeling in mice?

Population

Angiotensin II-induced hypertensive mice and mouse smooth muscle cells

Comparison

Smooth muscle cell Pde4d knockout vs controls

Design

Preclinical in vitro and in vivo animal study

Authors

TFTianfei FanYHYangfeng HouWGWeipeng Ge

Discussion

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Overview

Links PDE4D to hypertension; hypothesis-generating and requires clinical validation before any therapeutic consideration.

Structured PICO

Does Pde4d knockout attenuate Ang II-induced hypertension and vascular remodeling in mice?

P
Population
Angiotensin II (Ang II)-induced hypertensive mice and mouse smooth muscle cells (SMCs)
I
Intervention
Knockout of Pde4d in mouse smooth muscle cells
O
Outcome
Blood pressure, arterial wall media thickening, vascular fibrosis, and vasocontractionsurrogate

PDE4D promotes Ang II-induced hypertension via smooth muscle cell contraction, identifying it as a potential therapeutic target.

Cite This Study

Fan et al. (2021) studied this question.

synapsesocial.com/papers/6a710c85e5469ee92be1adc3https://doi.org/10.21203/rs.3.rs-344201/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction2022 · 18 citations
  2. 2Renal Phosphodiesterase 4B Is Activated in the Dahl Salt-Sensitive Rat2008 · 11 citations
  3. 3Expression of Phosphodiesterase 4D (PDE4D) Is Regulated by Both the Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinase Signaling Pathways2000 · 86 citations
  4. 4PDE4 Phosphodiesterases in Cardiovascular Diseases: Key Pathophysiological Players and Potential Therapeutic Targets2023 · 11 citations
  5. 5Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II2010 · 61 citations