Why the study?
Are pleconaril-resistant coxsackievirus B3 variants less virulent than wild type virus in a murine model?
Population
Murine model and cell culture infected with coxsackievirus B3
Comparison
Infection with pleconaril-resistant… vs Infection with wild type coxsackievirus B3
Design
Preclinical
Authors
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Attenuated virulence in resistant variants suggests fitness cost; leaves open whether findings translate to human enteroviral myocarditis.
Are pleconaril-resistant coxsackievirus B3 variants less virulent than wild type virus in a murine model?
Pleconaril-resistant coxsackievirus B3 variants are attenuated and significantly less virulent than the wild type virus in a murine model.
Groarke et al. (1999) studied this question.
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