February 10, 2014Echocardiography

High‐Intensity Focused Ultrasound Ablation of Myocardium In Vivo and Instantaneous Biological Response

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Why the study?

Does high-intensity focused ultrasound (HIFU) ablation create controllable myocardial lesions in vivo in a canine model?

Structured PICO

Does high-intensity focused ultrasound (HIFU) ablation create controllable myocardial lesions in vivo in a canine model?

Population

12 dogs (6 for in vivo beating heart ablation, 6 for in vitro fresh heart ablation)

Intervention

High-intensity focused ultrasound (HIFU) ablation of left ventricle myocardium at 3000 W/cm2 for 1.2, 2.4, 3.6, and 4.8 seconds

Comparator

In vitro ablation at the same energy levels (for lesion size comparison) and pre-ablation baseline (for functional and biomarker changes)

Outcome

Instantaneous biological response including lesion volume, focal maximum temperature, global cardiac function, focal wall motion, and cardiac biomarkerssurrogate

HIFU ablation can create controllable myocardial lesions in vivo, reducing regional wall motion while preserving global left ventricular function.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Regional wall motion reduction without EF change in canines; leaves open translation to human arrhythmia ablation.

Cite This Study

Zheng et al. (2014) studied this question.

synapsesocial.com/papers/6a710e4c35aa2c282ce25f61 https://doi.org/10.1111/echo.12526

View Full Paper

Ask AI

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High‐Intensity Focused Ultrasound Ablation of Myocardium In Vivo and Instantaneous Biological Response

Structured PICO

Discussion

Implication

Cite This Study

High‐Intensity Focused Ultrasound Ablation of Myocardium In Vivo and Instantaneous Biological Response

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider