July 13, 1999Circulation

Extracardiac Ablation of the Canine Atrioventricular Junction by Use of High-Intensity Focused Ultrasound

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Why the study?

Does high-intensity focused ultrasound ablation create complete AV block in a canine model?

Structured PICO

Does high-intensity focused ultrasound ablation create complete AV block in a canine model?

Population

10 anesthetized dogs undergoing thoracotomy

Intervention

High-intensity focused ultrasound (HIFU) ablation of the atrioventricular (AV) junction (1.4-MHz transducer, max intensity 2.8 kW/cm2, delivered during electrical diastole for 30 seconds per application)

Outcome

Creation of complete AV block and lesion characteristics (volume, depth, length, width, histopathology)surrogate

High-intensity focused ultrasound is a feasible energy source for creating complete AV block and well-demarcated lesions in a beating heart canine model.

Discussion

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Implication

Hypothesis-generating for HIFU in AV nodal ablation; leaves open safe human translation pending further studies.

Cite This Study

Strickberger et al. (1999) studied this question.

synapsesocial.com/papers/6a7d9ade603f5e16dd339a65 https://doi.org/10.1161/01.cir.100.2.203

Topics

Echocardiography

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Extracardiac Ablation of the Canine Atrioventricular Junction by Use of High-Intensity Focused Ultrasound

Structured PICO

Discussion

Implication

Cite This Study

Topics

Extracardiac Ablation of the Canine Atrioventricular Junction by Use of High-Intensity Focused Ultrasound

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider