Why the study?
Does neurovascular stimulation with acetylcholine reveal impaired skin microcirculation in Type I diabetes patients with neuropathy compared to those without neuropathy and healthy controls?
Population
30 subjects: 20 patients with Type I diabetes and 10 age-matched non-diabetic control subjects.
Comparison
Neurovascular stimulation by intracutaneous… vs Non-neuropathic diabetic patients and…
Design
Cross-sectional
Authors
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Impaired acetylcholine skin perfusion may signal neurovascular dysfunction in diabetic neuropathy; leaves open prospective validation for microcirculatory assessment in Type 1 diabetes.
Does neurovascular stimulation with acetylcholine reveal impaired skin microcirculation in Type I diabetes patients with neuropathy compared to those without neuropathy and healthy controls?
Type I diabetes patients with neuropathy have impaired total skin perfusion after acetylcholine stimulation, indicating a disturbance in the neurovascular reflex arc driven by diminished total and subpapillary blood flow rather than nutritive capillary flow.
Först et al. (1998) studied this question.
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