Key result
Type 1 diabetes patients with vascular complications exhibited significantly increased baseline and maximal skin capillary density in both extremities compared to healthy controls and patients without complications.
Cross-Sectional (n=135)
No
p-value: p=<0.05
Patients with type 1 diabetes and vascular complications exhibit increased functional and structural skin capillary density alongside a loss of microvascular autoregulatory capacity.
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Increased capillary density in complicated T1D may signal compensatory remodeling with lost autoregulation; hypothesis-generating and needs longitudinal validation before clinical use.
Tibiriçá et al. (2009) conducted a cross-sectional in Type 1 diabetes with and without vascular complications (n=135). Type 1 diabetes with vascular complications vs. Healthy controls and type 1 diabetes patients without complications was evaluated on Skin capillary density and recruitment (p=<0.05). Type 1 diabetes patients with vascular complications exhibited significantly increased baseline and maximal skin capillary density in both extremities compared to healthy controls and patients without complications.
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