What question did this study set out to answer?

To determine whether human bocavirus (HBoV) is an independent etiologic pathogen associated with severe pneumonia requiring hospitalization.

March 2, 2007The Journal of Infectious DiseasesOpen Access

Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

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Authors

AFAlicia M. FryIntermountain Healthcare XLXiaoyan LuUniversity College Dublin MCMalinee ChittaganpitchMinistry of Public Health

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Implication

Case-control study reveals human bocavirus significantly increases the risk of hospitalized pneumonia in young children, indicating pathogenesis may depend on viral coinfection.

Key Points

To determine whether human bocavirus (HBoV) is an independent etiologic pathogen associated with severe pneumonia requiring hospitalization.
Conducted a hospital-based case-control study between 1 September 2004 and 31 August 2005 in Thailand comparing patients hospitalized with pneumonia to 280 asymptomatic control patients.
Tested hospitalized pneumonia patients, 512 outpatients presenting with influenza-like illness, and controls for HBoV and 13 additional respiratory viruses.
HBoV infection was significantly associated with pneumonia requiring hospitalization compared with asymptomatic controls (adjusted OR, 3.56; 95% CI, 1.06–11.91; P=.04), occurring in 3.9% (20/512) of outpatients and 1.0% (3/280) of controls.
Viral coinfection occurred in 83% of hospitalized pneumonia cases and 90% of outpatients, with 83% of all HBoV pneumonia cases occurring in children younger than 5 years.
Wheezing was significantly more prevalent among pneumonia patients coinfected with HBoV and either RSV or HPIV than in those with RSV or HPIV alone (53% [9/17] vs. 23% [32/138]; P=.01).

Cite This Study

Fry et al. (2007) studied this question.

synapsesocial.com/papers/6a710f2b26a7f98052dd7d48 https://doi.org/10.1086/512163

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Implication

Case-control study reveals human bocavirus significantly increases the risk of hospitalized pneumonia in young children, indicating pathogenesis may depend on viral coinfection.

Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

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Implication

Key Points

Cite This Study

Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

Discussion

Member takes

Implication

Key Points

Cite This Study

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