The study identifies ILK, PKC, and ROCK as key mediators in the signal transduction pathway responsible for force potentiation in large arteries subjected to mechanical strain.
ILK-PKC-ROCK pathway mediates large-artery force potentiation; leaves open relevance to human BP autoregulation.
When subjected to mechanical strain, smooth muscle from large arteries has the ability to increase its force generation (force potentiation), which could be important in autoregulation of blood pressure. This phenomenon, however, does not involve a myogenic response, such as the one seen in small arteries and arterioles. Our work shows the involvement of ILK, PKC, and ROCK in the signal transduction pathway that mediates the force-potentiating effect of mechanical strain in large arteries.
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Wang et al. (2023) studied this question.
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