April 1, 1989Journal of Biological ChemistryOpen Access

Location of the Inhibitory Region of Smooth Muscle Myosin Light Chain Kinase

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Population

Gizzard smooth muscle myosin light chain kinase (MLC kinase)

Design

Preclinical

Authors

MIMitsuo IkebeGeneral Cardiology SMShinsaku MarutaSoka University SRS ReardonUniversity of Massachusetts Chan Medical School

Discussion

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Implication

Hypothesis-generating for MLCK-targeted modulators; leaves open translation to human cardiovascular therapies.

Structured PICO

Population

Gizzard smooth muscle myosin light chain kinase (MLC kinase)

Intervention

Proteolysis by trypsin in the presence or absence of Ca2+-calmodulin

Outcome

Location of the inhibitory domain and calmodulin-dependent kinase activity domainsurrogate

This basic science study identifies the specific amino acid sequences responsible for the inhibitory domain and calmodulin-dependent kinase activity in smooth muscle myosin light chain kinase.

Cite This Study

Ikebe et al. (1989) studied this question.

synapsesocial.com/papers/6a711045ac440176ef29bf2a https://doi.org/10.1016/s0021-9258(18)83525-6

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Location of the Inhibitory Region of Smooth Muscle Myosin Light Chain Kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Location of the Inhibitory Region of Smooth Muscle Myosin Light Chain Kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider