Why the study?
Does argatroban prevent mortality and ischemic damage in rats with ellagic acid-induced cerebral thromboembolism compared to saline or heparin?
Population
Rats with ellagic acid (EA)-induced cerebral thromboembolism
Comparison
Argatroban 3 mg/kg/h vs Saline control and Heparin 600 U/kg/h
Design
Preclinical
Follow-up
6 hours
Authors
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May outperform heparin without bleeding in rat thromboembolism; leaves open human stroke trials.
Does argatroban prevent mortality and ischemic damage in rats with ellagic acid-induced cerebral thromboembolism compared to saline or heparin?
Argatroban is more effective and safer than heparin for preventing ischemic damage and mortality in a rat model of cerebral thrombosis.
Hara et al. (2009) studied this question.
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