Why the study?
Does the amidolytic factor X assay accurately measure the extent of oral anticoagulation in patients receiving antithrombin drugs like argatroban?
Does the amidolytic factor X assay accurately measure the extent of oral anticoagulation in patients receiving antithrombin drugs like argatroban?
The amidolytic factor X assay provides a reliable alternative to PT/INR for monitoring oral anticoagulation in patients simultaneously receiving direct thrombin inhibitors like argatroban, which falsely elevate INR.
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May support amidolytic factor X assay for warfarin monitoring during argatroban; leaves open prospective validation before clinical adoption.
Hoppensteadt et al. (1997) studied this question.
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