Why the study?
Do anti-Xa and anti-IIa drugs alter International Normalized Ratio (INR) measurements in citrated plasma?
Do anti-Xa and anti-IIa drugs alter International Normalized Ratio (INR) measurements in citrated plasma?
Direct anti-Xa and anti-IIa agents can falsely elevate INR values in a concentration-dependent manner, highlighting the risk of dosing errors when monitoring patients on concomitant warfarin therapy.
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Direct inhibitors may artifactually elevate INR in animal plasma; leaves open translation to human samples and warfarin co-therapy.
Töbü et al. (2004) studied this question.
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