Why the study?
The effects of LCZ696 on remodeling of cardiac electrophysiology in animal models of myocardial infarction-induced heart failure remain largely unclear.
Does LCZ696 reduce ventricular tachyarrhythmia inducibility in a rat model of MI-induced heart failure?
Population
Sprague-Dawley rats with post-MI heart failure (LVEF <= 40%) and sham-operated rats
Comparison
LCZ696 vs enalapril vs vehicle vs sham operation
Design
Randomized preclinical animal study
Follow-up
4 weeks
Authors
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May reduce post-MI ventricular arrhythmia inducibility in rats; leaves open translation to human electrophysiology remodeling.
Does LCZ696 reduce ventricular tachyarrhythmia inducibility in a rat model of MI-induced heart failure?
In a rat model of MI-induced heart failure, LCZ696 (sacubitril/valsartan) reduced ventricular arrhythmia inducibility and upregulated K+ channel proteins compared to enalapril.
Chang et al. (2019) studied this question.
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