Why the study?
Does preoperative clopidogrel in combination with aspirin increase postoperative bleeding in patients undergoing urgent first-time CABG?
Population
300 patients undergoing urgent first-time coronary artery bypass graft surgery (CABG)
Comparison
Preoperative clopidogrel in combination with… vs No treatment with platelet antagonist 7 days…
Design
Cohort
Follow-up
Postoperative period (up to ICU discharge)
Authors
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Preoperative clopidogrel was associated with increased bleeding after urgent CABG; leaves open optimal timing strategies in observational data.
Does preoperative clopidogrel in combination with aspirin increase postoperative bleeding in patients undergoing urgent first-time CABG?
Preoperative administration of clopidogrel and aspirin before urgent CABG significantly increases postoperative bleeding, transfusion requirements, and morbidity.
Hoxha et al. (2018) studied this question.
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