What question did this study set out to answer?

To determine the effect of repeated pentobarbital administration on the disposition and hepatic extraction of oral and intravenous alprenolol.

September 1, 1977Clinical Pharmacology & Therapeutics

Effect of pentobarbital on the disposition of alprenolol

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To determine the effect of repeated pentobarbital administration on the disposition and hepatic extraction of oral and intravenous alprenolol.
Administered oral (200 mg) and intravenous (5.0 mg) alprenolol to healthy subjects (N=5) before and after 10 to 14 daily doses of 0.1 g pentobarbital.
Calculated plasma concentration-time curves, systemic elimination rates, hepatic extraction ratios, and clearance-derived hepatic blood flow.
Oral alprenolol area under the plasma concentration-time curve decreased from 706 ± 277 to 154 ± 48 ng/ml·hr following pentobarbital, corresponding to an increase in hepatic extraction from 0.72 ± 0.13 to 0.93 ± 0.01 with no significant change in elimination rate.
Intravenous alprenolol disposition and clearance-estimated hepatic blood flow showed no marked or statistically significant changes after pentobarbital administration.

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Implication

Pharmacokinetic study reveals pentobarbital increases oral alprenolol liver extraction in healthy adults, indicating drug-induced metabolic clearance.

Cite This Study

Alván et al. (1977) studied this question.

synapsesocial.com/papers/6a711b19a2d7cf2e39c2c139 https://doi.org/10.1002/cpt1977223316

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Implication

Pharmacokinetic study reveals pentobarbital increases oral alprenolol liver extraction in healthy adults, indicating drug-induced metabolic clearance.

Effect of pentobarbital on the disposition of alprenolol

Key Points

Discussion

Implication

Cite This Study

Effect of pentobarbital on the disposition of alprenolol

Key Points

Discussion

Implication

Cite This Study

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