Why the study?
Do long-acting calcium antagonists reduce cardiac events in patients with a healed MI compared to no calcium antagonists?
Population
6,428 patients with a healed myocardial infarction (MI)
Comparison
Calcium antagonists of varying half-lives vs No calcium antagonists
Design
Cohort
Authors
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Long-acting calcium antagonists were not associated with reduced cardiac events after healed MI; leaves open benefit of longer-acting agents like amlodipine.
Do long-acting calcium antagonists reduce cardiac events in patients with a healed MI compared to no calcium antagonists?
Long-acting calcium antagonists do not significantly reduce cardiac events in patients with a healed MI, although there is a correlation between longer half-life and lower hazard ratio.
Taniwa et al. (2005) studied this question.
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