What question did this study set out to answer?

This research aims to identify overexpressed secreted protein biomarkers in cancer tissues and serum for potential diagnostic and therapeutic uses.

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

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Randomized trial identifies overexpressed biomarkers in cancer tissues, suggesting new diagnostic and therapeutic pathways.

This research aims to identify overexpressed secreted protein biomarkers in cancer tissues and serum for potential diagnostic and therapeutic uses.
Utilized sequence-based algorithms to predict genes for secreted proteins from 12,500 sequences on microarrays.
Queried expression of 74 overexpressed genes in 150 carcinomas compared to 46 normal tissues.
Analyzed candidate proteins through immunohistochemistry and immunoassays to assess clinical significance.
Identified 74 genes overexpressed in cancer tissues, including alpha-fetoprotein and kallikreins 6 and 10 with clinical applications.
Macrophage inhibitory cytokine 1 levels elevated in serum of patients with metastatic prostate, breast, and colorectal carcinomas.
Demonstrated that combining multiple analyses can effectively delineate candidate biomarkers with potential clinical significance.

Welsh et al. (2003) studied this question.

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