Whipple Endocarditis without Gastrointestinal Disease

Letters4 April 2000Whipple Endocarditis without Gastrointestinal DiseaseMargo A. Smith, MDMargo A. Smith, MDWashington Hospital Center; Washington, DC 20010 (Smith)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest Gubler and colleagues' report on endocarditis due to Tropheryma whippelii without overt gastrointestinal involvement (1) and the accompanying editorial by Raoult (2). We recently evaluated a similar patient with culture-negative endocarditis due to T. whippelii, who also had no evident gastrointestinal manifestations.Our patient is a 78-year-old man who presented to the Washington Hospital Center in Washington, D.C., for cardiac revascularization and mitral valve replacement. He had a 5-year history of congestive heart failure and angina. His laboratory studies showed anemia of chronic disease. Outpatient bone marrow biopsy and endoscopy of upper and ...References1. Gubler JG, Kuster M, Dutly F, Bannwart F, Krause M, Vögelin HP, et al . Whipple endocarditis without overt gastrointestinal disease: report of four cases. Ann Intern Med. 1999;131:112-6. LinkGoogle Scholar2. Raoult D. Afebrile blood culture-negative endocarditis [Editorial]. Ann Intern Med. 1999;131:144-6. LinkGoogle Scholar3. Oakley CM. The medical treatment of culture-negative infective endocarditis. Eur Heart J. 1995;16 Suppl B 90-3. CrossrefMedlineGoogle Scholar4. Elkins C, Shuman TA, Pirolo JS. Cardiac Whipple's disease without digestive symptoms. Ann Thorac Surg. 1999;67:250-1. CrossrefMedlineGoogle Scholar5. Relman DA, Schmidt TM, MacDermott RP, Falkow S. Identification of the uncultured bacillus of Whipple's disease. N Engl J Med. 1992;327:293-301. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Margo A. Smith, MDAffiliations: Washington Hospital Center; Washington, DC 20010 (Smith) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWhipple Endocarditis without Overt Gastrointestinal Disease: Report of Four Cases Jacques G.H. Gubler , Marcel Kuster , Fabrizio Dutly , Fridolin Bannwart , Martin Krause , Hans Peter Vögelin , Gianni Garzoli , and Martin Altwegg Afebrile Blood Culture–Negative Endocarditis Didier Raoult Metrics Cited byTropheryma whipplei EndocarditisTropheryma whipplei Endocarditis: Case Presentation and Review of the LiteratureClinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei InfectionsTropheryma whipplei tricuspid endocarditis: a case report and review of the literatureEndocarditis due to Tropheryma whipplei: rapid detection, limited genetic diversity, and long-term clinical outcome in a local experienceWhipple DiseaseWhipple DiseaseWhipple's disease: new aspects of pathogenesis and treatmentWhipple's DiseaseMaladie de Whipple diagnostiquée primitivement sarcoïdoseEndocardites de la maladie de Whipple : cinq observations et revue de la littératureTropheryma whippelii as a cause of afebrile culture-negative endocarditis: the evolving spectrum of Whipple's disease 4 April 2000Volume 132, Issue 7Page: 595KeywordsBone marrowEndocarditisMitral valve replacementRibosomal RNAStainingSurgerySystolic ejection murmurThoracic surgeryVancomycinWeight loss ePublished: 15 August 2000 Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...