Key result
MicroRNA-146a inhibits oxLDL-induced dendritic cell maturation and inflammatory cytokine secretion by targeting CD40L.
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There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether miRNAs are associated with dendritic cell (DC) immuno-inflammatory responses to oxidized low density lipoprotein (oxLDL) stimulation is yet unknown. Our study aims to explore the link of miRNA to lipid-overload and the immuno-inflammatory mechanism for atherosclerosis. Human primary monocyte-derived DCs were transfected with miR-146a mimics and inhibitor, and then stimulated by oxLDL. For the flow cytometric analysis of the DC immunophenotype, supernatants were collected to determine inflammatory chemokine markers. Our study clearly revealed that miRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion in DCs by targeting CD40L in ox-LDL-stimulated DCs.
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Chen et al. (2011) studied Atherosclerosis. miR-146a mimics and inhibitor was evaluated on Dendritic cell maturation process and pro-inflammatory cytokine secretion. MicroRNA-146a transfection regulated the maturation process and pro-inflammatory cytokine secretion in oxLDL-stimulated human dendritic cells by targeting CD40L.
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