What question did this study set out to answer?

To determine the prevalence of rhinovirus, enterovirus, and coronavirus RNA in the nasopharynx of children undergoing elective surgery who lack current respiratory symptoms.

January 4, 2002Journal of Medical VirologyOpen Access

Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms

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Why the study?

What is the prevalence of respiratory viruses in the nasopharynx of children without concurrent respiratory symptoms?

Population

107 children without concurrent respiratory symptoms admitted to the hospital for elective surgery.

Comparison

RT-PCR testing of nasopharyngeal aspirates for… vs Children with versus without related past or…

Design

Cross-sectional

Follow-up

2 weeks post-surgery (questionnaire)

Authors

JNJohanna Nokso‐KoivistoUniversity of Helsinki TKTeemu J. KinnariUniversity of Helsinki PLPäivi LindahlUniversity of Helsinki

Discussion

Member takes

Implication

Asymptomatic viral detection is common post-infection in children; hypothesis-generating for transmission risk and should not yet change practice.

Key Points

To determine the prevalence of rhinovirus, enterovirus, and coronavirus RNA in the nasopharynx of children undergoing elective surgery who lack current respiratory symptoms.
Tested nasopharyngeal aspirates from N=107 asymptomatic pediatric surgical patients using RT-PCR for human rhino-, entero-, and coronaviruses.
Administered parental questionnaires tracking the presence of respiratory symptoms four weeks before and two weeks after surgical admission.
Viral RNA was present in 29% (31/107) of samples, with rhinovirus detected in 18% and enterovirus in 11%, whereas coronavirus was not detected in any child (0%).
Picornavirus RNA prevalence was significantly higher among children with past or recent respiratory infection compared to those without (45% vs. 20%, P = 0.008).
Among virus-positive children, 81% had previous symptoms or symptomatic family members, and only 4 of the 31 cases had no infection diagnosis or nearby symptomatic window.

Structured PICO

What is the prevalence of respiratory viruses in the nasopharynx of children without concurrent respiratory symptoms?

Population

107 children without concurrent respiratory symptoms admitted to the hospital for elective surgery.

Intervention

RT-PCR testing of nasopharyngeal aspirates for human rhino-, entero-, and coronaviruses

Comparator

Children with versus without related past or recent respiratory infection

Outcome

Prevalence of viral RNA (rhinovirus, enterovirus, coronavirus)

A significant proportion of children without concurrent respiratory symptoms harbor respiratory viruses, particularly if they have a recent history of respiratory infection.

Cite This Study

Nokso‐Koivisto et al. (2002) studied this question.

synapsesocial.com/papers/6a712ad38031ec7bb1dccda4 https://doi.org/10.1002/jmv.2161

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Implication

Asymptomatic viral detection is common post-infection in children; hypothesis-generating for transmission risk and should not yet change practice.

Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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