Why the study?
Is platelet aggregation and malondialdehyde formation increased in type IIA hypercholesterolemic patients compared to controls?
Population
25 type IIA hypercholesterolemic patients and 15 control subjects
Design
Case-control
Authors
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May indicate prothrombotic state in type IIA hypercholesterolemia; hypothesis-generating and requires prospective validation before clinical implications.
Is platelet aggregation and malondialdehyde formation increased in type IIA hypercholesterolemic patients compared to controls?
Type IIA hypercholesterolemia is associated with increased platelet reactivity and malondialdehyde formation, suggesting a prothrombotic state.
Tremoli et al. (2009) studied this question.
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