Why the study?
Do type-II hyperlipoproteinaemic patients have increased platelet sensitivity and thromboxane B2 formation compared to normolipidaemic controls?
Population
150 type-II hyperlipoproteinaemic patients (115 type IIA and 35 type IIB)
Design
Case-control
Authors
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Type-II hyperlipoproteinaemia was associated with pro-thrombotic platelet changes; hypothesis-generating and requires prospective validation before clinical implications.
Do type-II hyperlipoproteinaemic patients have increased platelet sensitivity and thromboxane B2 formation compared to normolipidaemic controls?
Type-II hyperlipoproteinaemia is associated with increased platelet sensitivity and thromboxane B2 formation, indicating a pro-thrombotic state in these patients.
Tremoli et al. (1984) studied this question.
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