Why the study?
Does P-407-induced hyperlipidemia increase myogenic reactivity and affect endothelial function in mesenteric arteries of pregnant rats?
Population
Pregnant rats on days 13-15 of pregnancy
Comparison
Single intraperitoneal injection of poloxamer 407 vs Sterile water vehicle or non-lipid-altering…
Design
Preclinical
Follow-up
4 days postinjection
Authors
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Hyperlipidemia may impair mesenteric endothelial function in pregnancy; hypothesis-generating for vascular complications and requires human validation.
Does P-407-induced hyperlipidemia increase myogenic reactivity and affect endothelial function in mesenteric arteries of pregnant rats?
Hyperlipidemia during pregnancy in a rat model increases myogenic reactivity in mesenteric arteries by attenuating NO-mediated vasodilation.
Ramirez et al. (2001) studied this question.
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