Population
Xenopus oocytes expressing functional homomeric mutant channels GIRK1(F137S) and GIRK4(S143T)
Comparison
Coexpression with muscarinic receptors… vs Wild-type heteromeric channels
Design
Preclinical
Authors
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Supports G-protein interaction sites in homologous GIRK1/4 regions; hypothesis-generating for cardiac KACh modulation, pending human validation.
Functionally important sites of interaction with G-proteins in cardiac KACh channels are likely located within the homologous regions of GIRK1 and GIRK4.
Vivaudou et al. (1997) studied this question.
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