January 1, 1998Canadian Journal of Physiology and Pharmacology

Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo

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Why the study?

Do PAR-1 and PAR-2 activating peptides elicit distinct hemodynamic responses in anesthetized mice?

Structured PICO

Do PAR-1 and PAR-2 activating peptides elicit distinct hemodynamic responses in anesthetized mice?

Population

Anesthetized mice

Intervention

Intravenous SFLLRN (0.1, 0.3, and 1 µmol/kg), SLIGRL (0.1, 0.3, and 1 µmol/kg), and TFLLRNPNDK (0.3, 1, and 3 µmol/kg), with or without L-NAME (nitric oxide synthesis inhibitor)

Comparator

Comparison between different receptor-activating peptides and baseline

Outcome

Mean arterial pressure (MAP) and heart rate (HR)surrogate

PAR-1 and PAR-2 activation produce distinct hemodynamic profiles in vivo, suggesting different roles in local vascular regulation.

Discussion

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Implication

PAR-1 and PAR-2 peptides elicit distinct hemodynamic effects in mice; hypothesis-generating for differential vascular roles in humans.

Cite This Study

Cheung et al. (1998) studied this question.

synapsesocial.com/papers/6a71328f2fdcb5703edb716c https://doi.org/10.1139/cjpp-76-1-16

View Full Paper

Ask AI

Bookmark

Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo

Structured PICO

Discussion

Implication

Cite This Study

Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider