Interaction between direct sympathetic and vagus nerve stimulation on heart rate in the isolated rabbit heart
Population
Innervated isolated rabbit heart preparation
Comparison
Vagus nerve stimulation at 2 Hz, 5 Hz, and 7 Hz… vs Varying levels of background sympathetic or…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports vagal dominance in isolated heart rate control; leaves open translation to in vivo human physiology.
Structured PICO
P
Population
Innervated isolated rabbit heart preparation
I
Intervention
Vagus nerve stimulation (VS) at 2 Hz, 5 Hz, and 7 Hz, and sympathetic stimulation (SS) at 2 Hz, 5 Hz, and 10 Hz
C
Comparator
Varying levels of background sympathetic or vagus nerve stimulation
O
Outcome
Intrinsic heart rate (chronotropic effects)surrogate
Vagal stimulation appears to play a dominant role over sympathetic stimulation in modulating heart rate in an isolated rabbit heart model.
Cite This Study
Brack et al. (2003) studied this question.