May 1, 2001Experimental Physiology
Effects of Direct Sympathetic and Vagus Nerve Stimulation on the Physiology of the Whole Heart – A Novel Model of Isolated Langendorff Perfused Rabbit Heart with Intact Dual Autonomic Innervation
Why the study?
Does direct sympathetic and vagus nerve stimulation affect heart rate and atrioventricular conduction in an isolated Langendorff perfused rabbit heart model?
Population
Isolated Langendorff perfused rabbit hearts with intact dual autonomic innervation (n=10)
Comparison
Direct sympathetic and vagus nerve stimulation vs Baseline (no stimulation)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform clinical practice; extends isolated heart models for direct autonomic studies on conduction.
Structured PICO
Does direct sympathetic and vagus nerve stimulation affect heart rate and atrioventricular conduction in an isolated Langendorff perfused rabbit heart model?
P
Population
Isolated Langendorff perfused rabbit hearts with intact dual autonomic innervation (n=10)
I
Intervention
Direct sympathetic and vagus nerve stimulation
C
Comparator
Baseline (no stimulation)
O
Outcome
Effects on intrinsic heart rate and atrioventricular conductionsurrogate
This novel isolated rabbit heart model allows for the study of direct autonomic nerve stimulation on whole heart physiology without the influence of circulating hormones or hemodynamic reflexes.
Cite This Study
Ng et al. (2001) studied this question.