January 1, 1993Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig.

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Why the study?

Does occlusion of the adventitial vasa vasorum cause arterial intimal hyperplasia in a porcine model?

Population

Yucatan miniature pigs (n=8 total: 4 for oxygenation profiles, 4 for survival experiments)

Comparison

Occlusion of the adventitial vasa vasorum by… vs Control vessels

Design

Preclinical

Authors

SBS. G. E. BarkerInstitute for the International Education of Students ATA TalbertKing's College School SCSimon CottamKing's College Hospital

Discussion

Member takes

Implication

Supports hypoxia hypothesis in atherosclerosis initiation; hypothesis-generating in porcine model, no clinical translation yet.

Structured PICO

Does occlusion of the adventitial vasa vasorum cause arterial intimal hyperplasia in a porcine model?

Population

Yucatan miniature pigs (n=8 total: 4 for oxygenation profiles, 4 for survival experiments)

Intervention

Occlusion of the adventitial vasa vasorum by flush ligation of the arterial branches that supply them

Comparator

Control vessels

Outcome

Production of a focal, intimal hyperplastic lesion (measured by intimal to medial ratios)surrogate

Occlusion of the vasa vasorum induces intimal hyperplasia in a porcine model, supporting the hypothesis that arterial wall hypoxia may initiate atherosclerosis.

Cite This Study

Barker et al. (1993) studied this question.

synapsesocial.com/papers/6a7135eeb27f15817827abd5 https://doi.org/10.1161/01.atv.13.1.70

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Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider