June 1, 1991European Journal of Clinical Investigation
Arterial wall hypoxia following thrombosis of the vasa vasorum is an initial lesion in atherosclerosis
Population
Rabbits (arterial wall models)
Design
Review
Authors
Discussion
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Member takes
Implication
Remains unproven whether vasa vasorum occlusion initiates atherosclerosis; hypothesis-generating and requires experimental validation.
Structured PICO
P
Population
Rabbits (arterial wall models)
I
Intervention
Pressure on the outside of arteries / occlusion of vasa vasorum
O
Outcome
Physical and biochemical changes characteristic of atherosclerosis (smooth muscle cell proliferation, cellular accumulation of cholesteryl esters)surrogate
Proposes the hypothesis that arterial wall hypoxia following vasa vasorum thrombosis is an initial lesion in atherosclerosis.
Cite This Study
Martin et al. (1991) studied this question.