Key result
Atheromatous plaques induce localized adventitial neovascularity and transmedial vascularization without entering the plaque.
Why the study?
The vascular pattern within the aortic wall during experimental atheromatosis was not fully characterized.
Population
29 rabbits with induced atheromatosis
Comparison
None; observational study of vessel patterns in aortic wall
Design
Experimental study of induced atheromatosis
Authors
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Adventitial neovascularity may precede plaque vascularization in experimental atheroma; leaves open human relevance and therapeutic targeting.
Experimental atheromatosis in rabbits demonstrates that plaques induce adventitial neovascularity and transmedial vascularization without luminal origin.
Herman et al. (1973) studied Experimental Atheromatosis (n=29). Induced atheromatosis was evaluated on Pattern of vessels within the aortic wall. Induced atheromatous plaques in rabbits caused localized congruent neovascularity in the deep adventitia and progressive transmedial vascularization without extending into the plaque.
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