Population
Indo-1-loaded human platelets
Comparison
Stimulation with adenosine diphosphate or… vs Lack of extracellular Ca2+
Design
Preclinical
Follow-up
< 5 seconds
Authors
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No immediate clinical implications for antiplatelet therapy; leaves open translation of agonist-specific calcium kinetics to human thrombosis models.
ADP and thrombin rapidly increase cytosolic calcium in human platelets within 0.5 seconds under physiological flow conditions, with distinct kinetic profiles.
Jones et al. (1988) studied this question.
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