Key result
Epinephrine potentiates ADP to elevate intracellular free calcium in human platelets.
Why the study?
Intracellular free calcium plays a key role as a second messenger in platelet activation, and post-receptor events can be investigated by measuring free calcium concentration in cells.
Population
Human platelets
Comparison
Adenosine-5'-diphosphate vs epinephrine and their combination
Design
In vitro methodological and pharmacological study
Authors
Loading...
These in vitro observations should not alter antiplatelet practice; leaves open epinephrine's role in human thrombosis models.
The study describes a method for measuring intracellular free calcium in human platelets using quin-2-tetraacetoxymethyl-ester and demonstrates the synergistic effect of epinephrine and ADP on calcium elevation.
Erné et al. (1984) studied this question. Adenosine-5'-diphosphate and epinephrine was evaluated on Intracellular free calcium concentration. Epinephrine potentiated the effect of adenosine 5'-diphosphate in elevating intracellular free calcium in human platelets, while epinephrine alone required another permissive factor.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: