Population
Gel-filtered platelets
Comparison
ADP and epinephrine vs Unstimulated platelets
Design
Preclinical
Authors
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Hypothesis-generating for platelet Ca2+ handling in animals; leaves open human relevance and clinical translation.
ADP and epinephrine stimulate platelet activation by increasing surface-bound calcium and the rate of intracellular calcium exchange, rather than causing a net influx of calcium.
Brass et al. (1982) studied this question.
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