Ca2+ mobilization in blood platelets as visualized by chlortetracycline fluorescence

View Full Paper

Ask AI

Bookmark

Population

Intact human blood platelets

Design

Preclinical

Authors

Discussion

Preclinical platelet data only; leaves open translation of cAMP-calcium effects to human antiplatelet strategies.

Population

Intact human blood platelets

Intervention

Epinephrine, A23187, U46619, prostaglandin E1, prostacyclin, and various inhibitors (verapamil, EDTA, indomethacin, RO201724)

Outcome

Intracellular Ca2+ binding and mobilizationsurrogate

Increases in platelet cAMP by prostaglandins enhance intracellular calcium binding and inhibit calcium mobilization induced by aggregating agents.

Owen et al. (1981) studied this question.

View Full Paper

Ask AI

Bookmark