Why the study?
Adaptive responses to arterial or arteriolar pressure elevation have typically been investigated in cross-sectional studies in hypertensive patients or longitudinal animal studies.
Does intermittent local vascular pressure elevation increase in vivo arterial stiffness in healthy individuals?
Population
Healthy individuals
Comparison
Fifteen 40-min moderate transmural pressure elevations
Authors
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May indicate local vascular adaptation in health; hypothesis-generating for hypertension and requires longitudinal confirmation.
Does intermittent local vascular pressure elevation increase in vivo arterial stiffness in healthy individuals?
Intermittent moderate transmural pressure elevations over 5 weeks increase arterial stiffness in healthy individuals, suggesting local mechanisms involving ET-1, Ang-II, and MMP-7 may contribute to the development of primary hypertension.
Eiken et al. (2021) studied this question.
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