Population
Conscious mice (intact, sham-lesioned, and area postrema-lesioned)
Comparison
Intravenous infusions of angiotensin II… vs Sham-lesioned vs area postrema-lesioned mice…
Design
Preclinical
Authors
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Area postrema is required for ANG II baroreflex resetting in mice; leaves open translation to human physiology or therapy.
In mice, the ability of angiotensin II to acutely reset baroreflex control of heart rate depends on an intact area postrema.
Xue et al. (2003) studied this question.
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