Why the study?
Does the area postrema mediate the attenuation of baroreflex control of heart rate by angiotensin II in conscious rabbits?
Population
Intact and area postrema-lesioned conscious rabbits
Comparison
Angiotensin II infusion and bolus injections vs Phenylephrine infusion and nitroprusside infusions
Design
Preclinical
Authors
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Area postrema mediates Ang II baroreflex resetting in rabbits; hypothesis-generating for central mechanisms but should not yet inform clinical practice.
Does the area postrema mediate the attenuation of baroreflex control of heart rate by angiotensin II in conscious rabbits?
The attenuation of baroreflex control of heart rate by angiotensin II results from resetting of the cardiac baroreflex, an effect mediated by the area postrema.
Matsukawa et al. (1990) studied this question.
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