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July 1, 1999AJP Heart and Circulatory Physiology

ANG II and baroreflex function in rabbits with CHF and lesions of the area postrema

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Why the study?

Does AT1-receptor blockade with L-158,809 improve baroreflex sensitivity in rabbits with CHF, and is this effect mediated by the area postrema?

Population

24 male New Zealand White rabbits, divided into sham and area postrema lesioned groups, each further divided…

Comparison

Intravenous administration of the AT1-receptor… vs Baseline and comparison between intact and…

Design

Preclinical

Follow-up

3-4 weeks of pacing

Authors

JLJun‐Li LiuLiaoning UniversityHMHiroshi MurakamiHiroshima UniversityMSMax G. SanderfordTarleton State University

Discussion

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Implication

Supports area postrema mediation of AT1 blockade on baroreflex in CHF rabbits; hypothesis-generating and leaves open human translation.

Structured PICO

Does AT1-receptor blockade with L-158,809 improve baroreflex sensitivity in rabbits with CHF, and is this effect mediated by the area postrema?

P
Population
24 male New Zealand White rabbits, divided into sham (n=12) and area postrema lesioned (n=12) groups, each further divided into normal and pacing-induced chronic heart failure (CHF) subgroups (n=6 each).
I
Intervention
Intravenous administration of the AT1-receptor antagonist L-158,809.
C
Comparator
Baseline (before administration of L-158,809) and comparison between intact and lesioned rabbits.
O
Outcome
Baroreflex sensitivity evaluated by heart rate (HR) and renal sympathetic nerve activity (RSNA) responses to infusions of phenylephrine and nitroprusside.surrogate

The area postrema mediates the normalization of baroreflex sensitivity following AT1 receptor blockade in a rabbit model of chronic heart failure.

Cite This Study

Liu et al. (1999) studied this question.

synapsesocial.com/papers/6a831af4c4b5dbf8331f2eb8https://doi.org/10.1152/ajpheart.1999.277.1.h342

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure1996 · 36 citations
  2. 2Angiotensin II attenuates baroreflex control of heart rate and sympathetic activity1984 · 180 citations
  3. 3Pressure-independent baroreflex resetting produced by chronic infusion of angiotensin II in rabbits1993 · 63 citations
  4. 4ANG II receptor blockade and arterial baroreflex regulation of renal nerve activity in cardiac failure1995 · 154 citations
  5. 5Cardiovascular consequences of microinjection of vasopressin and angiotensin II in the area postrema1993 · 34 citations