Population
Linear gramicidins with one, two, or three Trp----Phe substitutions in the gramicidin A sequence
Design
Preclinical
Authors
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No immediate clinical implications; leaves open the role of tryptophan in native mammalian channels.
Tryptophan-to-phenylalanine substitutions in gramicidin A independently decrease single-channel conductance, likely through electrostatic interactions, while exerting a complex influence on channel duration.
Becker et al. (1991) studied this question.
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