Population
Dictyostelium myosin II (cold-sensitive mutants G680V and G691C)
Comparison
G680V and G691C mutations vs Wild type myosin
Design
Preclinical
Authors
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Divergent mechanochemical defects from adjacent myosin mutations highlight sequence sensitivity; leaves open relevance to human cardiac myosinopathies.
The G680V and G691C mutations in Dictyostelium myosin II cause dramatically different biochemical defects in the mechanochemical cycle despite being separated by only 11 residues.
Patterson et al. (1997) studied this question.
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