Population
Dictyostelium discoideum myosin II and cells expressing mutant myosins
Comparison
Alanine scanning mutagenesis of the 'switch I'… vs Wild-type myosin II and myosin-null cells
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether homologous residues modulate human cardiac myosin function.
Identifies specific residues in the switch I loop of Dictyostelium myosin II critical for nucleotide binding and ATP hydrolysis.
Shimada et al. (1997) studied this question.
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