December 1, 1999Journal of Biological ChemistryOpen Access

Deletion of the Myopathy Loop of Dictyostelium Myosin II and Its Impact on Motor Functions

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Population

Dictyostelium myosin II (preclinical model)

Comparison

Deletion of the myopathy loop… vs Wild-type Dictyostelium myosin II (implied)

Design

Preclinical

Authors

NSNaoya SasakiKyoto Katsura Hospital HAHideo AsukagawaTokyo Metropolitan Komaba High School RYRyohei YasudaMax Planck Florida Institute for Neuroscience

Discussion

Member takes

Implication

Provides mechanistic insight into myosin myopathy loop function; leaves open relevance to human cardiovascular disease.

Structured PICO

Population

Dictyostelium myosin II (preclinical model)

Intervention

Deletion of the myopathy loop (Ile(398)-Leu-Ala-Gly-Arg-Asp(403)-Leu-Val(405)) or replacement of Asp(403) or Arg(402) with alanine

Comparator

Wild-type Dictyostelium myosin II (implied)

Outcome

Motor functions and hydrophobic interactions of actin and myosin during the ATPase cyclesurrogate

Deletion of the myopathy loop in Dictyostelium myosin II abolishes strong hydrophobic interactions with actin but preserves low-level motor functions, highlighting the role of its hydrophobic residue cluster.

Cite This Study

Sasaki et al. (1999) studied this question.

synapsesocial.com/papers/6a20aa717cf5d95c4e72e25a https://doi.org/10.1074/jbc.274.53.37840

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Deletion of the Myopathy Loop of Dictyostelium Myosin II and Its Impact on Motor Functions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deletion of the Myopathy Loop of Dictyostelium Myosin II and Its Impact on Motor Functions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider