Population
Dictyostelium myosin II (in vitro and in vivo models)
Comparison
Mutant myosin II with a deletion of 521 amino… vs Wild-type myosin II
Design
Preclinical
Authors
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Mutant myosin preserves in vitro motility yet impairs cytokinesis; leaves open tail domain requirements in mammalian cardiac models.
The proximal 58-kDa portion of the Dictyostelium myosin II tail is not required for basic motile activities but is necessary for optimal in vivo function.
Kubalek et al. (1992) studied this question.
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