July 1, 1999Journal of Cell Science

Role of myosin II tail sequences in its function and localization at the cleavage furrow in Dictyostelium

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Population

Dictyostelium cells from which the endogenous myosin heavy chain gene has been deleted

Design

Preclinical

Authors

SSShi ShuHohai University RLRandall J. LeeUniversity of California System JLJanine LeBlanc-StraceskiMerrimack College

Discussion

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Implication

No single tail domain is essential for myosin II function in Dictyostelium; leaves open redundant mechanisms in mammalian cytokinesis.

Structured PICO

Population

Dictyostelium cells from which the endogenous myosin heavy chain gene has been deleted

Intervention

Expression of myosins carrying mutations in the tail domain (internal tail deletions: Mydelta824-941, Mydelta943-1464, Mydelta943-1194, Mydelta1156-1464) and chimeric myosins (Dictyostelium myosin head and chicken skeletal myosin tail)

Outcome

Localization of mutant myosins to the cleavage furrow and ability to support cytokinesissurrogate

There is no single specific domain in the tail of Dictyostelium myosin II required for its localization to the cleavage furrow and function in cytokinesis.

Cite This Study

Shu et al. (1999) studied this question.

synapsesocial.com/papers/6a83582fb1437134e3ebf489 https://doi.org/10.1242/jcs.112.13.2195

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Role of myosin II tail sequences in its function and localization at the cleavage furrow in Dictyostelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of myosin II tail sequences in its function and localization at the cleavage furrow in Dictyostelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider