December 1, 2000Journal of Biological ChemistryOpen Access

Insertion or Deletion of a Single Residue in the Strut Sequence of Dictyostelium Myosin II Abolishes Strong Binding to Actin

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Population

Dictyostelium myosin II (myosin-null cells, purified full-length myosins and subfragment-1s)

Design

Preclinical

Authors

NSNaoya SasakiKyoto Katsura Hospital ROReiko OhkuraNorthwestern University KSKazuo SutohWaseda University

Discussion

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Implication

Dictyostelium results warrant caution before clinical translation; leaves open strut loop relevance in mammalian cardiac myosin.

Structured PICO

Population

Dictyostelium myosin II (myosin-null cells, purified full-length myosins and subfragment-1s)

Intervention

Insertion or deletion of a single residue in the strut sequence of myosin

Outcome

In vivo motor functions and strong binding to actin

The strut loop in Dictyostelium myosin II is functionally important for establishing the strong-binding state to actin and achieving successful power strokes.

Cite This Study

Sasaki et al. (2000) studied this question.

synapsesocial.com/papers/6a78d0586971db5bdd6736f8 https://doi.org/10.1074/jbc.m001966200

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Insertion or Deletion of a Single Residue in the Strut Sequence of Dictyostelium Myosin II Abolishes Strong Binding to Actin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insertion or Deletion of a Single Residue in the Strut Sequence of Dictyostelium Myosin II Abolishes Strong Binding to Actin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider