Measuring right ventricular function in the normal and hypertensive mouse hearts using admittance-derived pressure-volume loops
Population
Mice exposed to chronic hypoxia for 10 days to induce hypoxia-induced pulmonary hypertension and control mice.
Comparison
Exposure to chronic hypoxia for 10 days and… vs Control (CTL) mice.
Design
Preclinical
Follow-up
10 days
Authors
Discussion
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Implication
Validates admittance PV loops for RV assessment in murine HPH; leaves open translation to human pulmonary hypertension.
Structured PICO
P
Population
Mice exposed to chronic hypoxia for 10 days to induce hypoxia-induced pulmonary hypertension (HPH) and control (CTL) mice.
I
Intervention
Exposure to chronic hypoxia for 10 days (HPH model) and evaluation of cardiac reserve with dobutamine infusion.
C
Comparator
Control (CTL) mice.
O
Outcome
Right ventricular function parameters including RV mass, RV systolic pressure, cardiac output, and ventricular-vascular coupling efficiency (E(es)/E(a)) measured via admittance catheter.surrogate
Admittance-derived pressure-volume loops can feasibly measure right ventricular function and detect ventricular-vascular decoupling in a mouse model of hypoxia-induced pulmonary hypertension.
Cite This Study
Tabima et al. (2010) studied this question.