Why the study?
Does chlorthalidone at varying doses (25, 50, 100, 200 mg) reduce blood pressure and affect biochemical markers in patients with mild to moderate essential hypertension?
Population
37 patients with mild to moderate essential hypertension
Comparison
Chlorthalidone at daily doses of 25, 50, 100… vs Single-blind placebo intervals interspersed…
Design
RCT, Doses administered in random order, Active treatment periods were…
Follow-up
8 weeks per dose
Authors
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Supports 25-50 mg chlorthalidone initiation to balance BP efficacy and metabolic safety; extends RCT dose-response data for thiazide-like diuretics.
Does chlorthalidone at varying doses (25, 50, 100, 200 mg) reduce blood pressure and affect biochemical markers in patients with mild to moderate essential hypertension?
Chlorthalidone at doses of 25 or 50 mg daily provides maximal blood pressure reduction for most patients with mild to moderate hypertension while minimizing dose-dependent biochemical disturbances.
Tweeddale et al. (1977) studied this question.
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