Why the study?
Does lower dose chlorthalidone reduce blood pressure with fewer side effects compared to higher doses or placebo in patients with mild hypertension?
Population
100 patients with mild hypertension
Comparison
Chlorthalidone 12.5 mg, 25 mg, 50 mg, or 75 mg… vs Placebo for 12 weeks
Design
RCT, randomly assigned, doubleblind
Follow-up
12 wk
Authors
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25 mg chlorthalidone matches higher doses for BP reduction with less hypokalemia; challenges standard dosing recommendations and supports lower-dose optimization trials.
Does lower dose chlorthalidone reduce blood pressure with fewer side effects compared to higher doses or placebo in patients with mild hypertension?
A 25 mg daily dose of chlorthalidone is as effective as 50 mg and 75 mg for lowering blood pressure in mild hypertension, but causes less potassium depletion.
Materson et al. (1978) studied this question.
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