Why the study?
Does chlorthalidone combined with triamterene improve blood pressure control and prevent hypokalemia compared to chlorthalidone alone in patients with mild to moderate hypertension?
Population
129 patients with mild to moderate hypertension
Comparison
Chlorthalidone 25 mg plus triamterene 50 mg for… vs Chlorthalidone 25 mg alone for 10 weeks
Design
RCT, allocated at random, single-blind for placebo periods, double-blind for…
Follow-up
10 weeks, followed by 6-week partial crossover and 2-week…
Authors
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Chlorthalidone/triamterene achieves similar BP control with less hypokalemia; extends evidence for safer diuretic combinations in hypertension.
Does chlorthalidone combined with triamterene improve blood pressure control and prevent hypokalemia compared to chlorthalidone alone in patients with mild to moderate hypertension?
Adding triamterene to chlorthalidone maintains antihypertensive efficacy while significantly reducing the risk of hypokalemia compared to chlorthalidone alone.
Hart et al. (1991) studied this question.
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