Key result
Chlorthalidone 50 mg/triamterene 50 mg combination offered equivalent blood pressure reduction to chlorthalidone alone, but with significantly less decrease in serum potassium concentration.
Why the study?
Does chlorthalidone 50 mg/triamterene 50 mg combination treatment improve blood pressure reduction and prevent hypokalemia in patients with mild to moderate hypertension compared to chlorthalidone 50 mg alone?
Population
141 patients with mild to moderate hypertension
Comparison
Chlorthalidone 50 mg and triamterene 50 mg… vs Chlorthalidone 50 mg alone
Design
RCT, Double-blind
Authors
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Supports chlorthalidone-triamterene combination for equivalent BP control with less hypokalemia; extends RCT evidence for potassium-sparing strategies in hypertension.
RCT (n=141)
Double-blind
Does chlorthalidone 50 mg/triamterene 50 mg combination treatment improve blood pressure reduction and prevent hypokalemia in patients with mild to moderate hypertension compared to chlorthalidone 50 mg alone?
Adding triamterene 50 mg to chlorthalidone 50 mg maintains antihypertensive efficacy while significantly mitigating the risk of hypokalemia in patients with mild to moderate hypertension.
Spiers et al. (1996) conducted an RCT in mild to moderate hypertension (n=141). chlorthalidone and triamterene combination vs. chlorthalidone 50 mg was evaluated on clinical efficacy in the reduction of blood pressure, and safety with regard to serum potassium concentration and adverse reactions. Chlorthalidone 50 mg/triamterene 50 mg combination offered equivalent blood pressure reduction to chlorthalidone alone, but with significantly less decrease in serum potassium concentration.
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